Raptor Pharmaceuticals Announces Positive Phase 3 Trial Results: Shares Tumble

In a stunning an example of “buy the rumor sell the news,” Raptor Pharmaceuticals ( RPTP ) recently reported positive top-line data from its Phase 3 study of RP103 (reformulation of cysteamine bitartrate, DR Cysteamine) showing that RP103 met its primary endpoint in the study, non-inferiority compared to Cystagon and investors sold off immediately with the stock dropping from the high 6s to the mid 5s, before closing at 5 even. “Of 41 patients who completed the Phase 3 protocol, 38 were included in the evaluable data set, 3 not being fully compliant with the protocol. The age range of study participants was 6-26 years, with 87% of patients below 16 years old. On average, the peak WBC cystine level measured in patients treated with Cystagon(R) was 0.54 +/- 0.05 nmol 1/2 cystine/mg protein, compared to an average peak value of 0.62 +/- 0.05 nmol 1/2 cystine/mg protein for patients treated with RP103. The mean difference was 0.08 nmol 1/2 cystine/mg protein, with a 95.8% confidence interval of 0.00-0.16 (one sided p=0.021). As stipulated in the Statistical Analysis Plan, the non-inferiority endpoint of the clinical trial would be achieved when the upper end of the confidence interval around the mean difference of WBC cystine levels did not exceed an absolute value of 0.3. The upper end of the confidence interval in the Phase 3 clinical trial was determined to be 0.16, thus achieving the non-inferiority endpoint.” “In the course of the study, seven serious adverse events ("SAEs") requiring a visit to the emergency room or hospital, were reported for seven individual patients. Of these seven SAEs, six were determined by the Principal Investigator to be unrelated to either RP103 or Cystagon(R). One SAE, gastric intolerance, was graded as "possibly related" to RP103 and was subsequently resolved. Further analyses of non-serious adverse events ("AEs") are underway by the Company's statistical contractor.” Also, I believe they will be able to attract significant market share (~80% of the 500 patient population in the U.S.) making RP103 a meaningful revenue generator (400 patients multiplied by for example, $70,000/year is $28 MM, most of which will flow to the bottom line) and thus will help pay for the larger, more expensive and risky clinical trials in Raptor’s pipeline. Correct me if I am wrong, but the financing should come as no surprise given their cash situation?

Three Phase Generators - News


Raptor Pharmaceuticals Announces Positive Phase 3 Trial Results: Shares Tumble

In a stunning an example of “buy the rumor sell the news,” Raptor Pharmaceuticals (RPTP) recently reported positive top-line data from its Phase 3 study of RP103 (reformulation of cysteamine bitartrate, DR Cysteamine) showing that RP103 met its primary



Permanent magnet generators offer efficiency and flexibility

Generally when designing a PMG, Indar engineers consider a wide range of factors, including the contribution of magnet temperature, rotational speed, switching frequency and short-circuit (two-phase and three-phase) performance to achieve ideal magnet



Power finally restored to Ferndale; conservation still urged

Repairs to an underground cable were scheduled to be completed sometime this morning, and those DTE customers who had been relying upon three huge generators provided by the utility will once again be plugged into the overall system.



County Crew Knocks Down Pole; Hundreds Without Power
County Crew Knocks Down Pole; Hundreds Without Power

An EREC spokesperson said the Escambia County Road Department knocked down a three-phase pole that serves EREC's Bratt Substation. The county worker mowing with a tractor and Bush Hog was unable to see a guy wire on the pole on West Highway 4 near



Contracts & Projects Tracker: August 2011

Hyundai Engineering and Construction has given Foster Wheeler the go ahead to design and supply four 550 MWe supercritical circulating fluidized-bed (CFB) steam generators for the Samcheok Green Power project for Korea Southern Power Co.




3 phase generators: Powerhouse PH3100Ri 3100 Watt 6.8 HP 4-Stroke ...

Powerhouse PH3100Ri 3100 Watt 6.8 HP 4-Stroke Gas Powered Portable Inverter Generator With Remote Start (CARB Compliant) Feature 3,000 watts continuous/3,100 watts surge Enough power to run a 13,500 BTU RV air conditioning unit Variable speed/Constant speed settings for fuel economy and full power to fit your needs. Remote start at up to 75-feet away CARB Compliant 6.8 hp engine, powerful enough to run a 13,500btu rv a/c, remote electric start to 75?, built-in hour meter, automatic choke, one 20 amp duplex receptacle, fuel gauge, padded pull handle, swivel wheels included Ac output: rated / max (watts); 3000 / 3100 w. remote control, low noise, inverter equipped for safe use with electronic equipment, certifications; epa, carb, csa iso 9001 Variable speed for fuel economy as power demands, or constant speed for 100% full power, engine reset button, automatic low oil shutdown, emergency stop control, 2-year consumer /1year commercial warranty Powerhouse PH3100Ri 3100 Watt 6.8 HP 4-Stroke Gas Powered Portable Inverter Generator With Remote Start (CARB Compliant) Overview Powerhouse Products has combined quality, features and value in its new PH3100Ri inverter generator. The PH3100Ri has a 6.8 HP engine that provides the extra power needed to start a 13.5K RV air conditioner, while inverter technology makes it safe enough to power delicate electronic equipment. The engine can be set to run at variable speed for fuel economy as power demands or at constant speed for 100% full power. The PH3100Ri includes as standard features not included on most other leading brands of generators: a remote start to 75-feet, a built-in hour meter to track the total run time, and factory installed swivel wheels and pull handle for maximum maneuverability. Other standard features include an engine-reset button that will automatically restart the engine if the unit shuts down due to engine overload; one 5-20R 20 amp duplex receptacle; one L5-30R 30 amp twist lock receptacle; internal circuit breaker; fuel gauge, and emergency stop control. Continuous run time (hr) Full load; 7.6 hrs; 1/4 load; 17.8 hrs. EPA, CARB and CSA compliant. The PH3100Ri comes with an oil jug, 12V charge cable, spare spark plug, spark plug wrench & handle, oil drain extension, spare 10A glass tube fuse, user�s manual, keys and remote. Includes 2-year consumer warranty, 1-year commercial warranty.


Three Phase Generators - Bookshelf

Brotherhood of Locomotive Firemen's magazine

Brotherhood of Locomotive Firemen's magazine

The phases of a two-phase or three-phase generator will be electrically unbalanced if the electrical characteristics of either phase differ, ...

Renewable and efficient electric power systems

Renewable and efficient electric power systems

Figure 3.15 shows a 4-pole, 3-phase generator with a salient-pole rotor, which means it spins at only half the rotor speed compared to a 2-pole machine. ...

Transport world

Transport world

The three-phase generators (Fig. 15) were built by the Oerlikon Works, Zurich, and are coupled direct to the turbine shaft. They work at a pressure of 7000 ...

Power

Power

Each generator will have a capacity of 1000 horse-power and will weigh about 3Q, vtons. They will be the largest three-phase generators yet constructed. ...

Handbook of medical imaging, Physics and psychophysics

Handbook of medical imaging, Physics and psychophysics

The circuit diagram for three- phase generators is not shown. There are two variations in three phase generator circuits, resulting in so-called 6-pulse and ...

Daily Info Directory


Portable and Towable Three Phase Electric Power Generator ...
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Three Phase Generators
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Three Phase - Three Phase Power Converters & Generators
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Three Phase Generator Sales
TEMCo disdributes hundreds of models and brands of three phase power generators.